Health Care Utilization in Transplanted Versus Non-Transplanted Sickle Cell Disease Patients

Inflammatory Bowel Disease in Primary Sclerosing Cholangitis: Clinical Characteristics in Liver Transplanted and Non-Transplanted Patients

Cyclosporin versus tacrolimus for liver transplanted patients.

BACKGROUND Most liver transplant recipients receive either cyclosporin or tacrolimus to prevent rejection. Both drugs inhibit calcineurin phosphatase which is thought to be the mechanism of their anti-rejection effect and principle toxicities. The drugs have different pharmacokinetic profiles and potencies. Several randomised clinical trials have compared cyclosporin and tacrolimus in liver tra...

Inflammatory bowel disease in liver transplanted patients

Most common hepatobiliary manifestation of inflammatory bowel disease (IBD) are primary sclerosing cholangitis (PSC) and autoimmune hepatitis, ranking them as the main cause of liver transplantation (LT) in IBD setting. Course of pre-existing IBD after LT differs depending on many transplant related factors. Potential risk factors related to IBD deterioration after LT are tacrolimus-based immun...

Analysis of T-cell receptor variability in transplanted patients with acute graft-versus-host disease.

T lymphocytes play a pivotal role in graft-versus-host disease (GVHD) and largely contribute to the graft-versus-leukemia (GVL) effect. Most mature T lymphocytes specifically recognize antigens through the alpha/beta T-cell receptor (TCR). Each alpha/beta TCR chain includes a constant region and a variable region, the latter being encoded by V-J alpha or V-D-J beta rearranged gene segments. To ...

Infections in Transplanted Patients

Solid-organ transplantation is a therapeutic option for many end-stage diseases. One of the most common complications in the post-transplant period are different kind of infections. They are caused by some bacterial pathogens such as Legionella spp., Nocardia spp., Salmonella spp. and Listeria monocytogenes, many viral agents – Cytomegalovirus /CMV/, Herpes simplex virus / HSV/, Varicella-zoste...